The ITI team publishes a paper in DiabetesRegulatory T cells inhibit immune-responses and thus avoid auto-immune disease. Their activity is induced in part by activation of their T cell-receptor for antigen (TCR), which are expressed in a clonal manner, every Treg expressing its own TCR and thus having its own specificity. We hypothesised that the "repertoire" of TCRs expressed by Treg may be more restricted in type I diabetes-prone NOD mice than in mouse-strains resistant to autoimmune-disease. Thus, suppression of unwanted auto-immune-responses may be less efficient in these animals. However, our high throughput sequencing of TCRs expressed by Treg newly developed in the NOD mice and in control B6 mice demonstrated that their TCR-repertoires are similarly diverse.
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Véronique Adoue is awarded with the "Habilitation à Diriger des Recherches"On March 2nd 2021, Véronique presented, via videoconference, her professional career and research-projects in the context of her candidature for the "Habilitation à Diriger des Recherches", a French diploma and academic recognition. She brilliantly obtained her diploma. The whole team warmly congratulates her with this achievement!
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The ITI team publishes a paper in the European Journal of ImmunologyRegulatory T cells inhibit immune-responses and thus avoid auto-immune disease. It was therefore rather unexpected to find that in a mouse-line that spontaneously develops auto-immune type I ("juvenile") diabetes an unusually large number of these cells develops in the thymus of very young animals. In this paper we show that, rapidly after leaving the thymus, these cells go back there and strongly inhibit the development of new regulatory T cells
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The French National Agency for Research (ANR)
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The TMIT team publishes a paper in ImmunityDr. Olivier Joffre and his colleagues publish a paper in
"Immunity" on the control of T-lymphocyte differentiation by epigenetic mechanisms. |
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The members of the TMIT team mourn the tragic death of their much respected and beloved colleague Dr. Paola RomagnoliIn August 2018, Dr. Paola Romagnoli died in a tragic incident in the Raganello canyon in southern Italy. She will be dearly missed by all of her colleagues. May she rest in peace...
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Labretreat of the TMIT team in the "Gîte de Ségur"In spring of 2018, the TMIT team organised its labretreat at the charming Gîte de Ségur in Marzens where an equilibrated combination of scientific discussions, culinary adventures, and relaxing had an excellent effect on the life and creativity of the team
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The French National Agency for Research (ANR)
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"La Fondation pour la Recherche Médicale" continues its
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Dr Olivier Joffre publishes a paper in the journal Nature ImmunologyDr. Olivier Joffre, Associate Professor at the Toulouse University and staff-member of our team, has published work he has performed (with his colleagues) during his postdoc in Dr. Sebastien Amigorena's laboratory at the Curie-institute in Paris
and the first years of his appointment in Toulouse |
Gavin Vuddamalay demonstrates that
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The TMIT team publishes a paper in Nature ImmunologyDr. Paola Romagnoli and her colleagues published a paper in
Nature Immunology describing that peripheral regulatory T cells can migrate back to the organ in which they developed, the thymus. Recirculating regulatory T cells were found to inhibit development of their precursors |